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Medications like antidepressants can also be helpful to deal with underlying issues like depression or anxiety

Injectable BPC-157 is generally considered the most effective due to its higher bioavailability and direct delivery to the bloodstream

However, only one human study exists (for knee pain, not bone healing specifically)

Used as a research stack in laboratory models exploring tissue-repair biology and cell-migration science

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses