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Gonzlez, Universidad Autnoma de Nuevo Len, Monterrey, 64460, Mxico 11 Ted Rogers Center for Heart Research, Canada 12 Service of Endocrinology, Diabetes, Nutrition and Patient Therapeutic Education, Geneva University Hospitals, Geneva, Switzerland 13 Newbridge Surgery, Bath, UK 14 Sydney School of Public Health, The University of Sydney, Sydney, Australia 15 Centre for Kidney Research, The Childrens Hospital at Westmead, Sydney, Australia 16 Renal Division, Ghent University Hospital, Belgium 17 University of California Davis, USA 18 Department of Endocrinology, Clinic of Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway 19 K kumc gmail.com Abstract Clinical question What are the benefits and harms of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and glucagon-like peptide 1 (GLP-1) receptor agonists when added to usual care (lifestyle interventions and/or other diabetes drugs) in adults with type 2 diabetes at different risk for cardiovascular and kidney outcomes

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Using metformin alone can activate the AMPK pathway and inhibit the AKT pathway, while using simvastatin alone only inhibits the AKT pathway