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The more ancient family, here called the -type TrxRs for the species it was first described from (Moore et al., 1964), is found in all eubacteria, archaea, fungi, most protists, and most plants and algae (Fig

To induce long-term potentiation (LTP), Ca 2+ activates CAMKII and PKC, causing phosphorylation and insertion of AMPARs, while long-term depression (LTD) occurs by Ca 2+ activating protein phosphatases, which dephosphorylate and cause internalization of AMPARs

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