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Metformin carries minimal hypoglycemia risk and has 60+ years of safety data

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The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr

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Microglia, the primary immune responders in the brain, release proinflammatory cytokines when activated, which then stimulate nearby reactive astrocytes, amplifying local neuroinflammation