Overall, these SAR studies using the ternary complex structure including FBXO22, NSD2, and our next-generation NSD2 degrader, UNC10415667, revealed that UNC12149 is a more potent NSD2 degrader
staff at the Mass Spectrometry Resource Laboratory in the Center for Advanced Research Technologies (CART) and the Histology, Biochemistry, and Molecular Imaging (HBMI) Core at the Center for Musculoskeletal Research (CMSR) at URMC, the Proteomics/Metabolomics Core at Moffitt Cancer Center, which is funded in part by Moffitts Cancer Center Support Grant (P30CA076292), and University of Chicago Metabolomics Platform (RRID: SCR_022932)
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Additionally, the microbiomes in these treatment groups were compared to both age-matched lean and obese controls
"We ask people to invest something real at the front door because the evaluation is the treatment decision," Dr