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This is why fatigue on semaglutide and GLP-1 fatigue are so common

Slows Gastric Emptying The medication delays how quickly food leaves the stomach, promoting a sensation of fullness that supports portion control and reduces snacking behaviors

Nutrition Considerations Unique to GLP-1 Users Eat Smaller, More Frequent Meals Large meals can worsen nausea or discomfort due to slowed digestion

Standard titration begins at 0.25 mg weekly for 4 weeks, increasing to 0.5 mg for 4 weeks, then 1 mg for 4 weeks, with further increases to 1.7 mg and finally 2.4 mg at monthly intervals for weight management protocols

Singh, Chauhan, and Shri, 2021)