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Subsequent animal studies confirmed dose-dependent GH pulse amplification, additive effects with GHRH, and a favorable tolerability profile with repeat administration without tachyphylaxis (receptor desensitization) at doses studied

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Further information on data access and application procedures is available at Abbreviations ACEIs: Angiotensin-converting enzyme inhibitors AHMs: Antihypertensive medications aOR: Adjusted odds ratio ARB: Angiotensin II receptor blocker ASMD: Absolute standardised mean difference AT1 / AT4: Angiotensin II type 1/type 4 receptors BBs: Beta-blockers BP: Blood pressure CCB: Calcium channel blocker CI: Confidence interval DHP CCBs: Dihydropyridine calcium channel blockers HR: Hazard ratio IDGC: Independent data governance committee (MedicineInsight) NSAIDs: Non-steroidal anti-inflammatory drugs Non-DHP CCBs: Non-dihydropyridine calcium channel blockers OR: Odds ratio PDC: Proportion of days covered PSM: Propensity score matching RAS: Reninangiotensin system RCTs: Randomised controlled trials SD: Standard deviation VIF: Variance inflation factor References Livingston, G

Among oral treatments, methotrexate is the most strongly associated with hepatotoxicity, with long-term use linked to hepatic fibrosis and cirrhosis