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Obesity 26 , 14671473 (2018)

The criteria for liver injury were vacuolization of hepatocytes and pyknotic hepatocyte nuclei, activation of Kupffer cells, and enlargement of sinusoids

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rodentium (colon) and Salmonella elevate O 2 and nitrate concentrations above the epithelium causing a shift in IEC metabolism, similar to the impact caused by a reduction in butyrate-producing microbes described previously (Rivera-Chvez et al

Each of these pathways is facilitated by non-regulated mechanisms prevalent in cancer cells, leading to desensitization to treatment over time [11,12,13, 28,29,30,31,32]