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The dynamic tree cutting algorithm revealed 11 modules of genes co-regulated by either treatment or time ranging in size from 179 to 4418 genes (Supplementary Fig
The evidence combined BPC 157 with the time-dependently activated VEGFR2-Akt-eNOS signaling pathway, the increase in endothelial tube formation (chick chorioallantoic membrane (CAM)) (both suppressed by Dynasore, an endocytosis inhibitor), the increased expression and internalization of VEGFR2, and essential acceleration of blood flow recovery and vessel number to rescue hind limb ischemia in rats with a completely excised femoral artery [94]
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