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Moreover, small molecules activating ferroptosis through System X c inhibition or GPX4 inhibition enhance the antitumor effect of radiotherapy (Ye et al., 2020

53 African populations demonstrate unique genetic advantages through higher frequencies of BCL2 protective variants promoting melanocyte survival, distinct ASIP gene polymorphisms affecting melanin production, and population-specific KIT ligand variants influencing MSCs maintenance

In the SURMOUT-1 trial 2,539 patients underwent randomization to tirzepatide or placebo and were followed for 72 weeks demonstrating up to 20.9% weight reduction with maintenance dosing versus 3.1% in the placebo group for a net 17.8% weight reduction [35]

Under this scenario, a correlation between IGF-1 and MetS can be established

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