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Our study is observational and these results should therefore be replicated in a randomised controlled trial to confirm and extend our findings, said Dr Max Taquet, Clinical Lecturer at the University of Oxford and senior author of the study

Semaglutide has been associated with slightly higher reporting odds ratios for depression and self-injury compared to tirzepatide, which has only four reported suicidal events in European databases

164 The carnitine palmitoyl transferases (CPT), the rate-limiting enzymes in the FAO pathway, transport long-chain acyl-CoA from the cytosol to mitochondria

Originally approved for diabetes, these medications quickly became the most powerful pharmaceutical weight-loss option in history