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A dose-response study of the most promising derivatives confirmed a high potency and duration of action with an ED50 below 2 nmol/kg (calculated as the delta area under the curve [AUC] for blood glucose 48 h following subcutaneous dosing) ( The remainder of this review describes the pharmacology of liraglutide and semaglutide

doi: 10.1002/jcp.28010 189 ShenXBChenXZhangZYWuFFLiuXH

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All seven investigations point in the same direction on the forest plot, and the fact that the confidence intervals for each research are completely to the left of the null line (0.00) suggests that this conclusion is robust (Figure 5)