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The increased oxidative stress and TLR4 also contribute to the activation of NLRP3 inflammasome and hence to cardiac fibrosis

In addition, patients with hereditary folate absorption disorders also have a folate transporter disorder in the central nervous system, suggesting that PCFT is also involved in the transport of folate to the brain [112]

139 This is consistent with the hypothesis that elevated canonical Wnt signalling contributes to the hyperproliferation of embryonic neural progenitor cells (NPCs) in the brain, which may partially explain the macrocephaly observed in individuals with autism

19 , e20210109 (2022)