A further study employing a 3D model of goblet cell hyperplasia found that a six-week exposure period using whole smoke from the 3R4F Kentucky reference cigarette demonstrated a significant decrease in transepithelial electrical resistance and an increase in MUC5AC positive cells (cells expressing mucin) whilst exposure to aerosol from the THP1.0 did not (Haswell et al., 2021)
J Fire Sci 19(5):331397 Sasaki F, Matsuyama K, Tanaike Y, Nagawa Y, Ogino K, Uyama K, Uetake M, Matsufuji T, Sekizawa A (2013) Experimental study on the effectiveness of RIP cigarettes to fire ignition
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With the Geek Bar Pulse's 800mg total nicotine content and approximately 15,000 puffs in Regular Mode , you're looking at around 0.05mg of nicotine per puff (if we're being purely mathematical about it)