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While 10% of regular alcohol drinkers and 15% of cocaine users will become chemically dependent, nicotine permanently enslaves the brains of up to 90% of regular users

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In the body, the nicotine molecule gets protonated, and it forms both a strong cation-pi interaction with a tryptophan residue and a hydrogen bond to a tryptophan carbonyl group in the brain's acetylcholine receptor